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218 diseases ranked by how much harm they cause, how little research attention they get, and how much there is to build on. Every number comes from public data.

218
Diseases tracked
142
Ranked by burden
1.9B
Healthy years lost
72,231
Active trials counted

The neglect map

High burden, few trials

Each dot is a disease. The further up and left, the fewer clinical trials it has for the size of the problem.

1101001k10k1k10k100k1M10M100MActive clinical trials →Healthy years lost per year (DALYs) →100 trials per 1M10 trials per 1M1 trial per 1M↖ MORE NEGLECTEDMORE ATTENTION ↘Ischemic heart disease: 192.4M DALYs, 1981 active trialsStroke: 156.4M DALYs, 2832 active trialsAtrial fibrillation: 9.3M DALYs, 1010 active trialsCardiomyopathy: 12.0M DALYs, 585 active trialsPeripheral arterial disease: 1.9M DALYs, 358 active trialsAortic aneurysm: 3.4M DALYs, 260 active trialsEndocarditis: 2.3M DALYs, 63 active trialsMyocarditis: 649k DALYs, 87 active trialsPulmonary arterial hypertension: 701k DALYs, 187 active trialsLung cancer: 46.6M DALYs, 3989 active trialsColorectal cancer: 26.2M DALYs, 2721 active trialsBreast cancer: 24.6M DALYs, 4548 active trialsStomach cancer: 22.5M DALYs, 1064 active trialsLiver cancer: 13.9M DALYs, 1198 active trialsPancreatic cancer: 12.3M DALYs, 1302 active trialsProstate cancer: 8.9M DALYs, 2141 active trialsEsophageal cancer: 14.0M DALYs, 759 active trialsCervical cancer: 13.3M DALYs, 776 active trialsOvarian cancer: 6.5M DALYs, 1103 active trialsBladder cancer: 4.6M DALYs, 687 active trialsKidney cancer: 4.1M DALYs, 718 active trialsBrain cancer: 9.2M DALYs, 816 active trialsLeukemia: 12.2M DALYs, 2445 active trialsAcute myeloid leukemia: 4.2M DALYs, 1021 active trialsNon-Hodgkin lymphoma: 8.3M DALYs, 1730 active trialsHodgkin lymphoma: 1.2M DALYs, 184 active trialsMultiple myeloma: 2.8M DALYs, 1105 active trialsMelanoma: 1.8M DALYs, 882 active trialsThyroid cancer: 1.6M DALYs, 362 active trialsHead and neck squamous cell carcinoma: 15.9M DALYs, 771 active trialsUterine cancer: 2.9M DALYs, 1090 active trialsMesothelioma: 624k DALYs, 143 active trialsNeuroblastoma: 333k DALYs, 188 active trialsRetinoblastoma: 283k DALYs, 36 active trialsGallbladder cancer: 4.0M DALYs, 80 active trialsChronic obstructive pulmonary disease: 74.8M DALYs, 793 active trialsAsthma: 25.8M DALYs, 671 active trialsInterstitial lung disease: 4.5M DALYs, 507 active trialsPneumoconiosis: 532k DALYs, 8 active trialsTuberculosis: 43.6M DALYs, 288 active trialsHIV infection: 45.1M DALYs, 1205 active trialsPneumonia: 98.7M DALYs, 1156 active trialsCOVID-19: 32.1M DALYs, 657 active trialsDiarrheal disease: 56.5M DALYs, 150 active trialsTyphoid fever: 5.4M DALYs, 16 active trialsHepatitis B: 21.6M DALYs, 304 active trialsHepatitis C: 14.7M DALYs, 104 active trialsPertussis: 10.1M DALYs, 32 active trialsTetanus: 1.2M DALYs, 38 active trialsMeningitis: 17.5M DALYs, 71 active trialsSyphilis: 6.8M DALYs, 51 active trialsGonorrhea: 78k DALYs, 39 active trialsChlamydia infection: 184k DALYs, 42 active trialsHerpes zoster: 827k DALYs, 109 active trialsDengue: 3.0M DALYs, 55 active trialsYellow fever: 310k DALYs, 16 active trialsRabies: 871k DALYs, 17 active trialsEncephalitis: 4.3M DALYs, 106 active trialsChagas disease: 285k DALYs, 7 active trialsVisceral leishmaniasis: 332k DALYs, 10 active trialsCutaneous leishmaniasis: 754k DALYs, 18 active trialsAfrican trypanosomiasis: 85k DALYs, 2 active trialsSchistosomiasis: 2.1M DALYs, 15 active trialsLymphatic filariasis: 1.5M DALYs, 11 active trialsOnchocerciasis: 872k DALYs, 8 active trialsTrachoma: 145k DALYs, 4 active trialsLeprosy: 19k DALYs, 12 active trialsHookworm infection: 455k DALYs, 6 active trialsTrichuriasis: 282k DALYs, 8 active trialsCysticercosis: 1.2M DALYs, 4 active trialsEchinococcosis: 97k DALYs, 5 active trialsScabies: 3.2M DALYs, 8 active trialsAlzheimer disease: 39.7M DALYs, 1051 active trialsParkinson disease: 8.0M DALYs, 1144 active trialsEpilepsy: 15.4M DALYs, 589 active trialsMigraine: 40.9M DALYs, 338 active trialsMultiple sclerosis: 1.1M DALYs, 759 active trialsAmyotrophic lateral sclerosis: 1.2M DALYs, 293 active trialsTension-type headache: 4.6M DALYs, 34 active trialsAutism spectrum disorder: 9.8M DALYs, 605 active trialsMajor depressive disorder: 47.5M DALYs, 737 active trialsAnxiety disorder: 55.4M DALYs, 2464 active trialsBipolar disorder: 7.6M DALYs, 282 active trialsSchizophrenia: 17.0M DALYs, 636 active trialsAttention deficit hyperactivity disorder: 3.7M DALYs, 312 active trialsAnorexia nervosa: 847k DALYs, 139 active trialsBulimia nervosa: 3.0M DALYs, 72 active trialsAlcohol use disorder: 18.0M DALYs, 357 active trialsOpioid use disorder: 12.8M DALYs, 360 active trialsCocaine use disorder: 1.5M DALYs, 36 active trialsConduct disorder: 4.8M DALYs, 73 active trialsType 2 diabetes mellitus: 87.0M DALYs, 1689 active trialsType 1 diabetes mellitus: 3.1M DALYs, 700 active trialsGout: 1.8M DALYs, 72 active trialsMetabolic dysfunction-associated steatotic liver disease: 3.6M DALYs, 444 active trialsVitamin A deficiency: 1.1M DALYs, 13 active trialsCirrhosis of liver: 42.9M DALYs, 645 active trialsInflammatory bowel disease: 1.6M DALYs, 900 active trialsCrohn disease: 413k DALYs, 517 active trialsUlcerative colitis: 1.2M DALYs, 507 active trialsPeptic ulcer disease: 6.0M DALYs, 55 active trialsGastroesophageal reflux disease: 6.4M DALYs, 249 active trialsPancreatitis: 4.2M DALYs, 234 active trialsAppendicitis: 1.5M DALYs, 67 active trialsGallstones: 8.2M DALYs, 87 active trialsChronic kidney disease: 46.2M DALYs, 1079 active trialsDiabetic nephropathy: 12.6M DALYs, 119 active trialsKidney stones: 990k DALYs, 222 active trialsLow back pain: 70.4M DALYs, 642 active trialsNeck pain: 20.7M DALYs, 295 active trialsOsteoarthritis: 22.4M DALYs, 1249 active trialsRheumatoid arthritis: 3.3M DALYs, 571 active trialsPreeclampsia: 3.1M DALYs, 235 active trialsPostpartum hemorrhage: 3.2M DALYs, 72 active trialsPreterm birth: 70.2M DALYs, 919 active trialsNeonatal encephalopathy: 55.0M DALYs, 154 active trialsCongenital heart disease: 26.5M DALYs, 562 active trialsNeural tube defect: 4.0M DALYs, 60 active trialsEndometriosis: 1.9M DALYs, 262 active trialsPolycystic ovary syndrome: 653k DALYs, 163 active trialsCataract: 7.1M DALYs, 264 active trialsGlaucoma: 684k DALYs, 326 active trialsAge-related macular degeneration: 517k DALYs, 402 active trialsHearing loss: 53.1M DALYs, 380 active trialsRefractive error: 5.2M DALYs, 351 active trialsPsoriasis: 2.6M DALYs, 427 active trialsAtopic eczema: 11.1M DALYs, 328 active trialsAcne: 1.2M DALYs, 132 active trialsSickle cell anemia: 4.3M DALYs, 272 active trialsBeta thalassemia: 1.0M DALYs, 93 active trialsIron deficiency anemia: 39.3M DALYs, 143 active trialsG6PD deficiency: 552k DALYs, 5 active trialsHypertensive heart disease: 28.4M DALYs, 9 active trialsRheumatic heart disease: 14.5M DALYs, 26 active trialsMalaria: 51.6M DALYs, 126 active trialsMeasles: 12.5M DALYs, 20 active trialsAscariasis: 803k DALYs, 2 active trialsSnakebite envenomation: 4.8M DALYs, 8 active trialsIodine deficiency: 2.2M DALYs, 5 active trialsNeonatal sepsis: 22.7M DALYs, 53 active trials

Hover or tap a dot to see the disease. Click to open its page.

  1. 1Hypertensive heart disease
  2. 2Measles
  3. 3Snakebite envenomation
  4. 4Rheumatic heart disease
  5. 5Iodine deficiency
  6. 6Neonatal sepsis
  7. 7Malaria
  8. 8Ascariasis

Dashed lines mark 100, 10 and 1 active trial for every million healthy years lost each year. Trial counts measure attention, not progress, and some burden figures are broader than the disease (see each page). Not plotted, under 1k healthy years lost in 2023: Zika virus infection, Ebola hemorrhagic fever.

The leaderboard

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142 of 142 ranked

76 more diseases are tracked but not ranked yet, because they have no global burden estimate. Most are rare genetic diseases.