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Cardiovascular

Hypertensive heart disease

Abnormal enlargement of the heart resulting from long-standing hypertension.

Balanced: 21st of 142Biggest burden: 23rd of 142Most neglected: 1st of 142

Starter kit · coming soon

Start building on hypertensive heart disease

See a finished example: the malaria starter kit →

Where the field stands

  1. 01

    Early understanding

    No strong gene target or drug candidate yet

  2. 02

    Target found

    At least one gene target with strong evidence

  3. 03

    Drug candidates

    Preclinical or phase 1 drug candidates

  4. 04

    In trials

    Drug candidates in phase 2 or later

  5. 05

    Has approved drugs

    At least one approved drug; not necessarily a cure

Derived from Open Targets drug and target data, not self-reported.

Healthy years lost (DALYs), 2023

28.4M

95% range 22.7M to 35.2M

Deaths, 2023

1.5M

People living with it, 2023

13.4M

GBD cause: Hypertensive heart disease (exact match)

Research attention

Active clinical trials

9

All clinical trials, ever

34

Papers published, 2025

193

Active trials per million healthy years lost

0.3

Lower means fewer trials for the size of the problem

What there is to build on

Open Targets Platform ↗

Gene targets with strong evidence

0

of 311 associated genes

Top associated genes

FTOFGF5UMODAPOL1KCNK3

Drugs and clinical candidates

3

Approved drugs

0

Identifiers

Open Targets
MONDO_0001302
ICD-10
I11

Read these numbers with care

Trial and paper counts are rough measures of attention, not of progress. This page is for research planning, not medical advice.