Cardiovascular
Ischemic heart disease
Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (CABG); previous percutaneous coronary intervention (PCI); previous myocardial infarction. (ACC)
Starter kit · coming soon
Start building on ischemic heart disease
Open datasets
Imaging, genomics, clinical and text data you can use today
Benchmarks
Existing tasks and leaderboards to measure against
Open questions
Unsolved problems where a model could help
See a finished example: the malaria starter kit →
Where the field stands
01
Early understanding
No strong gene target or drug candidate yet
02
Target found
At least one gene target with strong evidence
03
Drug candidates
Preclinical or phase 1 drug candidates
04
In trials
Drug candidates in phase 2 or later
05
Has approved drugs
At least one approved drug; not necessarily a cure
Derived from Open Targets drug and target data, not self-reported.
Healthy years lost (DALYs), 2023
192.4M
95% range 175.6M to 208.8M
Deaths, 2023
8.9M
People living with it, 2023
239.4M
GBD cause: Ischemic heart disease (exact match)
Research attention
What there is to build on
Open Targets Platform ↗Gene targets with strong evidence
100+
of 6,771 associated genes
Top associated genes
APOELDLRGUCY1A1PCSK9HMGCR
Drugs and clinical candidates
241
Approved drugs
30
Identifiers
- Open Targets
- MONDO_0005010
- MeSH
- D003324
Trial and paper counts are rough measures of attention, not of progress. This page is for research planning, not medical advice.